Twenty-four patients were reported to have RBC alloimmunization, resulting in an overall prevalence of 5.4%. The most common causes of CLD in our center are viral hepatitis (62.1%) and metabolic liver disease (25.4%). A total of 441 CLD patients were included in our study, with the majority being elderly, with the mean age of patients 57.9 (SD ± 12.1) years old, male (65.1%) and Malays (92.1%). Clinical and laboratory data were retrieved and statistically analyzed. This is a case-control study involving 441 patients with CLD who were being treated at Hospital Universiti Sains Malaysia and subjected to pre-transfusion testing from April 2012 until April 2022. We aimed to determine the prevalence of RBC alloimmunization and associated factors among chronic liver disease (CLD) patients in our center. Variations in the frequency of alloimmunization have been noted among different patient populations. Red blood cell (RBC) alloimmunization is an important complication of blood transfusion.
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